Andrew Bergen, Ph.D., Senior Scientist

Contact

Education & Training

B.A., 1984
Haverford College, Haverford, PA
Biology

M.A., 1992
Johns Hopkins University, Baltimore, MD
Human Genetics

Ph.D., 1996
George Washington University, Washington, DC
Genetics

Dr. Bergen's research spans aging, psychiatric and substance use disorders. Dr. Bergen is a principal investigator of translational projects focused on developing biomarkers and models for treatment of tobacco use disorder and opioid use disorder. Dr. Bergen serves as a member of scientifiic consortia, and committee member of and consultant to non-profit and for-profit organizations.

Current Projects

Smokescreen Translational (TL) Analysis Platform

PROJECT PERIOD

09/01/18 - 08/31/20

FUNDING AGENCY

National Institute of Alcohol Abuse and Alcoholism (NIAAA)

CURRENT STATUS

Active and Not Recruiting

TEAM

Principal Investigator
Andrew Bergen

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Salivary Biomarkers (DNA, RNA and Cortisol), Life Stress and Nicotine Dependence

PROJECT PERIOD

09/30/09 - 08/31/12

FUNDING AGENCY

National Institute on Drug Abuse (NIDA)

CURRENT STATUS

Completed

TEAM

Principal Investigator
Judy Andrews, Andrew Bergen

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Publications

Gouveia, M. H., Bergen, A. W., Borda, V., Nunes, K., Leal, T. P., (27 additional coauthors), Tarazona-Santos, E., Mbulaiteye, S. M. (2019). Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genet. 2019 Mar 8;15(3):e1008027. doi: 10.1371/journal.pgen.1008027.

Abstract or Full Text

Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A. ... Bulik, C. M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet. 2019 Aug;51(8):1207-1214. doi: 10.1038/s41588-019-0439-2.

 

 

Cil, G., Park, J., & Bergen, A. W. (2019). Self-reported prescription drug use for pain and for sleep and incident frailty. Journal of the American Geriatrics Society.

Abstract or Full Text

Panagiotou, O. A., Schuit, E., Munafò, M. R., Bennett, D. A., Bergen, A. W., David, S. P. (2019). Smoking Cessation Pharmacotherapy Based on Genetically-Informed Biomarkers: What is the Evidence? Nicotine Tob Res. 2019 Aug;21(9):1289-1293. doi:10.1093/ntr/ntz009.

Abstract or Full Text

Bergen, A. W., Do, E. K., Chen, L.-S., David, S. P. (2019). Tobacco Genomics: Complexity and Translational Challenges. Nicotine Tob Res. 2019 Apr 24. doi:10.1093/ntr/ntz033.

Abstract or Full Text

Anttila et al. (2018). Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757.

Abstract or Full Text

Bergen, A. W. (2018). Biomarkers for Tobacco Exposures, Toxicology, Regulation and Cessation. Nicotine Tob Res, Mar 6;20(4):401-402.

Abstract or Full Text

Baurley, J. W., McMahan, C. S., Ervin, C. M., Pardamean, B., Bergen, A. W. (2018). Biosignature Discovery for Substance Use Disorders using Statistical Learning. Trends Mol Med. 2018 Feb;24(2):221-235. doi: 10.1016/j.molmed.2017.12.008. Epub 2018 Feb 4.

Abstract or Full Text

Johansson J. U., Brubaker W. D., Javitz H., Bergen A. W., Nishita D., Trigunaite A., Crane A., Ceballos J., Mastroeni D., Tenner A.J., Sabbagh M., Rogers J. Peripheral complement interactions with amyloid β peptide (Aβ) in Alzheimer’s disease: polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement. 2018 Nov;14(11):1438-1449. doi: 10.1016/j.jalz.2018.04.003. Epub 2018 May 21.

Abstract or Full Text

Hinney, A. et al. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry. 2017 Feb;22(2):192-201. doi: 10.1038/mp.2016.71. Epub 2016 May 17.

Abstract or Full Text

Schuit, E., Panagiotou, O. A., Munafò, M. R., Bennett, D. A., Bergen, A. W., David, S. P. (2017). Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. Cochrane Database Syst Rev. 2017 Sep 8;9:CD011823. doi: 10.1002/14651858.CD011823.pub2.

Abstract or Full Text

Duncan, L., Yilmaz, Z., Gaspar, H., Walters, R., Goldstein, J., Anttila, V., Bulik-Sullivan, B., Ripke, S. Eating Disorders Working Group of the Psychiatric Genomics Consortium., Thornton, L., Hinney, A., Daly, M., Sullivan, P. F., Zeggini, E., Breen, G., Bulik, C. M. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. Am J Psychiatry. 2017 Sep 1;174(9):850-858. doi: 10.1176/appi.ajp.2017.16121402.

Abstract or Full Text

Schwantes-An, T. H., et al. (2016). Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 2016 Mar;46(2):151-69.

Abstract or Full Text

Shih, P. B, Yang, J., Morisseau, C., German, J. B., Zeeland, A. A., Armando, A. M., Quehenberger, O., Bergen, A. W., Magistretti, P., Berrettini, W., Halmi, K.A,, Schork, N., Hammock, B. D., & Kaye, W. (2016). Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry. 2016 Apr;21(4):537-46.

Abstract or Full Text

David, S. P., Wang, A., Kapphahn, K., Hedlin, H., Desai, M., Henderson, M., Yang, L., Walsh, K. M., Schwartz, A. G., Wiencke, J. K., Spitz, M. R., Wenzlaff, A. S., Wrensch, M. R., Eaton, C. B., Furberg, H., Mark Brown, W., Goldstein, B. A., Assissmes, T., Tang, H., Kooperberg, C. L., Quesenberry, C. P., Tindle, H., Patel, M. I., Amos, C. I., Bergen, A. W., Swan, G. E., & Stefanick, M. L. Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. (2016). EBioMedicine. 2016 Jan 11;4:153-61. doi: 10.1016/j.ebiom.2016.01.002. eCollection 2016 Feb.

Abstract or Full Text

Baurley, J.W., Edlund, C.K., Pardamean, C.,, Conti, D. V., Krasnow, R., Javitz, H. S., Hops, H., Swan, G., Benowitz. N. L., & Bergen, A. W. (2016). Genome-wide association of the laboratory-based nicotine metabolite ratio in three ancestries. Nicotine Tob Res. 2016 Sep;18(9):1837-1844.

Abstract or Full Text

Guo, Y., Wei, Z., Keating, B. J.; Genetic Consortium for Anorexia Nervosa; Wellcome Trust Case Control Consortium; Price Foundation Collaborative Group, & Hakonarson, H. (2016). Machine learning derived risk prediction of anorexia nervosa. BMC Med Genomics. 2016 Jan 20;9:4.

Abstract or Full Text

Baurley, J. W., Edlund, C. K., Pardamean, C. I., Conti, D. V., Bergen, A. W. (2016). Smokescreen: a targeted genotyping array for addiction research. BMC Genomics. 2016 Feb 27;17:145.

Abstract or Full Text

Bergen, A. W., Krasnow, R., Javitz, H. S., Swan, G. E., Li, M. D., Baurley, J. W., Chen, X., Murrelle, L., & Zedler, B. Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures (2015). BMC Public Health. 2015 Sep 7;15:866.

Abstract or Full Text

Experience

2019 Board Member, Oregon Research Institute Eugene, OR

2018-present Member, Mental Health Advisory/Local Alcohol and Drug Planning Committee Lane County

2018-present Consultant, BioRealm, LLC Walnut, CA

2018-2020 MPI, R44AA027675 Smokescreen Translational (TL) Analysis Platform MPIs: Baurley & Bergen

2018 MPI, R43 DA046325 Biosignatures of opioid addiction treatment success MPIs: Baurley & Bergen

2017-present Senior Scientist, Oregon Research Institute Eugene, OR

2017 Consultant, Westat, Inc. Rockville, MD

2017 Consultant, Granite Point Ventures Greenbelt, MD

2016 MPI, R43 DA041211 Smokescreen Translational (TL) Analysis Platform MPIs: Baurley & Bergen

2015-present Associate, BioRealm LLC Walnut, CA

2015-2018 Member, Pharmacogenomics of Nicotine Addiction Treatment Research Group

2014-present Member, Tobacco Addiction Group Cochrane Collaboration

2014-present Member, Psychiatric Genomics Consortium

2014-present Scientific Advisor, BioRealm, LLC Walnut, CA

2014 Center for Tobacco and Alcohol Studies Visiting Professorship, School of Experimental Psychology University of Bristol UK

2012-2015 PI, R21 DA033813 DMET Genes, Nicotine Metabolism and Prospective Abstinence

2011 Statistical Analysis of Genome Scale Data, Cold Spring Harbor Laboratory Cold Spring Harbor, NY

2009-2012 MPI, RC2DA028793 Salivary Biomarkers, Life Stress and Nicotine Dependence MPIs: Andrews & Bergen

2009-2011 Co-I, R01 CA071358 Treatment of Nicotine Dependence in a Health Care Setting PI: Swan

2009-2010 Research Steering Committee Member Metabolic SNPs and Nicotine and Cotinine Metabolism in Two Family Based Samples    
(Medco Health Solutions and Affymetrix, Members: Bergen & Swan)

2008-2009 Research Steering Committee Member, Resequencing Candidate Genes of Interest in Nicotine Dependence
(Perlegen BioSciences, Members: Bergen & Swan)   

2007-2015 Director, Program in Molecular Genetics Center for Health Sciences, SRI International Menlo Park, CA

2007-2014 Co-I, U01 DA020830 Pharmacogenetics of Nicotine Addiction Treatment MPIs: Benowitz, Lerman, & Tyndale

2007-2009 Co-I, P50 CA084735 Genes, Environment & Tobacco Use Across Cultures PI: Johnson

2002-2006 Member, Core Genotyping Facility User Oversight Committee, Division of Cancer Epidemiology and Genetics
National Cancer Institute Rockville, MD

2002-2006 Adjunct Assistant Professor, Epidemiology and Biostatistics, George Washicngton University Washington, DC

2002-2007 Staff Scientist, Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda, MD

2002-2006 Principal, Andrew W. Bergen, LLC

1999-2001 Co-Founder, Laboratory Director, & Vice President, Biognosis U.S., Inc. Gaithersburg, MD

1999-present Co-Investigator, Environment and Genetics in Lung Cancer Etiology, Division of Cancer Epidemiology and Genetics
National Cancer Institute Rockville, MD

1998 Twin and Family Studies Workshop Institute for Behavioral Genetics, University of Colorado Boulder, CO

1998 Genetic-Epidemiologic Studies of Complex Diseases Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

1997-1999 Cancer Genetics and Epidemiology Post-Doctoral Fellowship, National Cancer Institute Rockville, MD

1996-1997 Post-Doctoral IRTA Fellowship, National Institute of Alcoholism and Alcohol Abuse Rockville, MD

1993-1996 Pre-Doctoral IRTA Fellowship, National Institute of Alcoholism and Alcohol Abuse Rockville, MD

1989 Mammalian Genetics Jackson Laboratory Bar Harbor, ME

1988-1991 NIH Pre-Doctoral Training Award, Johns Hopkins University Baltimore, MD

1987-1988 Research Associate, Cellmark Diagnostics Germantown, MD

1985-1987 Research Technician, Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University Baltimore, MD

Recent Research

Substance Use Disorders

PubMed 31111930 Selected genomic studies and future translation of genomic findings

PubMed 29409736 Genomic modeling of the Nicotine Metabolite Ratio (the NMR)

PubMed 27113016 First multiple ancestry genome-wide association study (GWAS) of the NMR


Eating Disorders

Genetic Markers for Anorexia Nervosa Press Release 07/16/2019

PubMed 31308545 Meta-GWAS of anorexia nervosa, Psychiatric Genomics Consortium (PGC-ED)

PubMed 30287268 Anorexia Nervosa Genetics Initiative overview and methods

PubMed 29155802 Exome-chip based GWAS, common, low frequency and rare variants, PGC-ED


Malaria Related Research

PubMed 30849090 African genomic admixture, ancestry and selection

PubMed 29033373 Mendelian Randomization, beta hemoglobin and endemic Burkitt Lymphoma

PubMed 28320389 Malaria infection in endemic Burkitt Lymphoma areas of Northern Uganda