Andrew Bergen, Ph.D., Senior Scientist

Contact

Education & Training

B.A., 1984
Haverford College, Haverford, PA
Biology

M.A., 1992
Johns Hopkins University, Baltimore, MD
Human Genetics

Ph.D., 1996
George Washington University, Washington, DC
Genetics

Andrew Bergen, Ph.D., is a Senior Scientist at Oregon Research Institute. His research interests include eating and substance use disorders with a focus on biomarkers and the genetics of risk and response to treatment. He is a member of academic consortia and scientific society working groups, and serves as a consultant to public and private sector organizations.

Current Projects

Smokescreen Translational (TL) Analysis Program

PROJECT PERIOD

09/01/18 - 08/31/20

FUNDING AGENCY

National Institute of Alcohol Abuse and Alcoholism (NIAAA)

CURRENT STATUS

Active and Not Recruiting

TEAM

Principal Investigator
Andrew Bergen

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Salivary Biomarkers (DNA, RNA and Cortisol), Life Stress and Nicotine Dependence

PROJECT PERIOD

09/30/09 - 08/31/12

FUNDING AGENCY

National Institute on Drug Abuse (NIDA)

CURRENT STATUS

Completed

TEAM

Principal Investigator
Judy Andrews, Andrew Bergen

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Publications

Gouveia, M. H., Bergen, A. W., Borda, V., Nunes, K., Leal, T. P., (27 additional coauthors), Tarazona-Santos, E., Mbulaiteye, S. M. (2019). Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genet. 2019 Mar 8;15(3):e1008027. doi: 10.1371/journal.pgen.1008027.

Abstract or Full Text

Panagiotou, O. A., Schuit, E., Munafò, M. R., Bennett, D. A., Bergen, A. W., David, S. P. (2019). Smoking Cessation Pharmacotherapy Based on Genetically-Informed Biomarkers: What is the Evidence? Nicotine Tob Res. 2019 Jan 25. doi: 10.1093/ntr/ntz009.

Abstract or Full Text

Bergen, A. W., Do, E. K., Chen, L.-S., David, S. P. (2019). Tobacco Genomics: Complexity and Translational Challenges. Nicotine Tob Res. 2019 Apr 24. doi:10.1093/ntr/ntz033.

Abstract or Full Text

Anttila et al. (2018). Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757.

Abstract or Full Text

Bergen, A. W. (2018). Biomarkers for Tobacco Exposures, Toxicology, Regulation and Cessation. Nicotine Tob Res, Mar 6;20(4):401-402.

Abstract or Full Text

Baurley, J. W., McMahan, C. S., Ervin, C. M., Pardamean, B., Bergen, A. W. (2018). Biosignature Discovery for Substance Use Disorders using Statistical Learning. Trends Mol Med. 2018 Feb;24(2):221-235. doi: 10.1016/j.molmed.2017.12.008. Epub 2018 Feb 4.

Abstract or Full Text

Johansson J. U., Brubaker W. D., Javitz H., Bergen A. W., Nishita D., Trigunaite A., Crane A., Ceballos J., Mastroeni D., Tenner A.J., Sabbagh M., Rogers J. Peripheral complement interactions with amyloid β peptide (Aβ) in Alzheimer’s disease: polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement. 2018 Nov;14(11):1438-1449. doi: 10.1016/j.jalz.2018.04.003. Epub 2018 May 21.

Abstract or Full Text

Hinney, A. et al. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry. 2017 Feb;22(2):192-201. doi: 10.1038/mp.2016.71. Epub 2016 May 17.

Abstract or Full Text

Schuit, E., Panagiotou, O. A., Munafò, M. R., Bennett, D. A., Bergen, A. W., David, S. P. (2017). Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. Cochrane Database Syst Rev. 2017 Sep 8;9:CD011823. doi: 10.1002/14651858.CD011823.pub2.

Abstract or Full Text

Duncan, L., Yilmaz, Z., Gaspar, H., Walters, R., Goldstein, J., Anttila, V., Bulik-Sullivan, B., Ripke, S. Eating Disorders Working Group of the Psychiatric Genomics Consortium., Thornton, L., Hinney, A., Daly, M., Sullivan, P. F., Zeggini, E., Breen, G., Bulik, C. M. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. Am J Psychiatry. 2017 Sep 1;174(9):850-858. doi: 10.1176/appi.ajp.2017.16121402.

Abstract or Full Text

Schwantes-An, T. H., et al. (2016). Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 2016 Mar;46(2):151-69.

Abstract or Full Text

Shih, P. B, Yang, J., Morisseau, C., German, J. B., Zeeland, A. A., Armando, A. M., Quehenberger, O., Bergen, A. W., Magistretti, P., Berrettini, W., Halmi, K.A,, Schork, N., Hammock, B. D., & Kaye, W. (2016). Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry. 2016 Apr;21(4):537-46.

Abstract or Full Text

David, S. P., Wang, A., Kapphahn, K., Hedlin, H., Desai, M., Henderson, M., Yang, L., Walsh, K. M., Schwartz, A. G., Wiencke, J. K., Spitz, M. R., Wenzlaff, A. S., Wrensch, M. R., Eaton, C. B., Furberg, H., Mark Brown, W., Goldstein, B. A., Assissmes, T., Tang, H., Kooperberg, C. L., Quesenberry, C. P., Tindle, H., Patel, M. I., Amos, C. I., Bergen, A. W., Swan, G. E., & Stefanick, M. L. Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. (2016). EBioMedicine. 2016 Jan 11;4:153-61. doi: 10.1016/j.ebiom.2016.01.002. eCollection 2016 Feb.

Abstract or Full Text

Baurley, J.W., Edlund, C.K., Pardamean, C.,, Conti, D. V., Krasnow, R., Javitz, H. S., Hops, H., Swan, G., Benowitz. N. L., & Bergen, A. W. (2016). Genome-wide association of the laboratory-based nicotine metabolite ratio in three ancestries. Nicotine Tob Res. 2016 Sep;18(9):1837-1844.

Abstract or Full Text

Guo, Y., Wei, Z., Keating, B. J.; Genetic Consortium for Anorexia Nervosa; Wellcome Trust Case Control Consortium; Price Foundation Collaborative Group, & Hakonarson, H. (2016). Machine learning derived risk prediction of anorexia nervosa. BMC Med Genomics. 2016 Jan 20;9:4.

Abstract or Full Text

Baurley, J. W., Edlund, C. K., Pardamean, C. I., Conti, D. V., Bergen, A. W. (2016). Smokescreen: a targeted genotyping array for addiction research. BMC Genomics. 2016 Feb 27;17:145.

Abstract or Full Text

Bergen, A. W., Krasnow, R., Javitz, H. S., Swan, G. E., Li, M. D., Baurley, J. W., Chen, X., Murrelle, L., & Zedler, B. Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures (2015). BMC Public Health. 2015 Sep 7;15:866.

Abstract or Full Text

Experience

2019
Board Member
Oregon Research Institute
Eugene, OR

2018 - present
Member
Mental Health Advisory/Local Alcohol and Drug Planning Committee
Lane County Board of Commissioners, Lane County, OR

2018 - present
Consultant
BioRealm, LLC

2017- present
Senior Scientist
Oregon Research Institute
Eugene, OR

2017
Consultant
Westat, Inc.
Rockville, MD

2017
Consultant
Granite Point Ventures
Greenbelt, MD

2015-present
Associate
BioRealm LLC
Walnut, CA

2015-present
Member
Pharmacogenomics Research Network: Pharmacogenetics of Nicotine Addiction Treatment (PGRN-PNAT) Research Group

2014-present
Member
Tobacco Addiction Group
Cochrane Collaboration

2014-present
Member
Psychiatric Genomics Consortium

2014-present
Scientific Advisor
BioRealm, LLC
Walnut, CA

2014
Center for Tobacco and Alcohol Studies Visiting Professorship
School of Experimental Psychology
University of Bristol
Bristol, England

2011
Statistical Analysis of Genome Scale Data 
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY

2007-2015
Director, Program in Molecular Genetics
Center for Health Sciences
SRI International
Menlo Park, CA

2007-2014
Co-Investigator
Pharmacogenetics of Nicotine Addiction Treatment Consortium

2002-2006
Member
Core Genotyping Facility User Oversight Committee
Division of Cancer Epidemiology and Genetics
National Cancer Institute
Rockville, MD

2002-2006
Adjunct Assistant Professor
Epidemiology and Biostatistics
George Washicngton University
Washington, DC

2002-2007
Staff Scientist
Division of Cancer Epidemiology and Genetics
National Cancer Institute
Bethesda, MD

2002-2006
Principal
Andrew W. Bergen, LLC

1999-2001
Co-Founder, Laboratory Director, & Vice President,
Biognosis U.S. Inc.
Gaithersburg, MD

1999-present
Co-Investigator
Environment and Genetics in Lung Cancer Etiology
Division of Cancer Epidemiology and Genetics
National Cancer Institute
Rockville, MD

1998
Twin and Family Studies Workshop
Institute for Behavioral Genetics
University of Colorado
Boulder, CO

1998
Genetic-Epidemiologic Studies of Complex Diseases
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY

1997-1999
Cancer Genetics and Epidemiology Post-Doctoral Fellowship,
National Cancer Institute
Rockville, MD

1996-1997
Post-Doctoral IRTA Fellowship,
National Institute of Alcoholism and Alcohol Abuse
Rockville, MD

1993-1996
Pre-Doctoral IRTA Fellowship
National Institute of Alcoholism and Alcohol Abuse
Rockville, MD

1989
Mammalian Genetics
Jackson Laboratory
Bar Harbor, ME

1988-1991
NIH Pre-Doctoral Training Award,
Johns Hopkins University
Baltimore, MD

1987-1988
Research Associate,
Cellmark Diagnostics
Germantown, MD

1985-1987
Research Technician
Department of Biochemistry
School of Hygiene and Public Health
Johns Hopkins University
Baltimore, MD