Andrew Bergen, Ph.D., Senior Scientist

Contact

Education & Training

B.A., 1984
Haverford College, Haverford, PA
Biology

M.A., 1992
Johns Hopkins University, Baltimore, MD
Human Genetics

Ph.D., 1996
George Washington University, Washington, DC
Genetics

Andrew Bergen, Ph.D., is a Senior Scientist at Oregon Research Institute. His research interests include eating and substance use disorders with a focus on biomarkers and the genetics of risk and response to treatment. He is a member of academic consortia and scientific society working groups, and serves as a consultant to public and private sector organizations.

Current Projects

Smokescreen Translational (TL) Analysis Program

PROJECT PERIOD

09/01/18 - 08/31/20

FUNDING AGENCY

National Institute of Alcohol Abuse and Alcoholism (NIAAA)

CURRENT STATUS

Active and Not Recruiting

TEAM

Principal Investigator
Andrew Bergen

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Salivary Biomarkers (DNA, RNA and Cortisol), Life Stress and Nicotine Dependence

PROJECT PERIOD

09/30/09 - 08/31/12

FUNDING AGENCY

National Institute on Drug Abuse (NIDA)

CURRENT STATUS

Completed

TEAM

Principal Investigator
Judy Andrews, Andrew Bergen

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Publications

Gouveia, M. H., Bergen, A. W., Borda, V., Nunes, K., Leal, T. P., (27 additional coauthors), Tarazona-Santos, E., Mbulaiteye, S. M. (2019). Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genet. 2019 Mar 8;15(3):e1008027. doi: 10.1371/journal.pgen.1008027.

Abstract or Full Text

Panagiotou, O. A., Schuit, E., Munafò, M. R., Bennett, D. A., Bergen, A. W., David, S. P. (2019). Smoking Cessation Pharmacotherapy Based on Genetically-Informed Biomarkers: What is the Evidence? Nicotine Tob Res. 2019 Jan 25. doi: 10.1093/ntr/ntz009.

Abstract or Full Text

Bergen, A. W., Do, E. K., Chen, L.-S., David, S. P. (2019). Tobacco Genomics: Complexity and Translational Challenges. Nicotine Tob Res. 2019 Apr 24. doi:10.1093/ntr/ntz033.

Abstract or Full Text

Anttila et al. (2018). Analysis of shared heritability in common disorders of the brain. Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757.

Abstract or Full Text

Bergen, A. W. (2018). Biomarkers for Tobacco Exposures, Toxicology, Regulation and Cessation. Nicotine Tob Res, Mar 6;20(4):401-402.

Abstract or Full Text

Baurley, J. W., McMahan, C. S., Ervin, C. M., Pardamean, B., Bergen, A. W. (2018). Biosignature Discovery for Substance Use Disorders using Statistical Learning. Trends Mol Med. 2018 Feb;24(2):221-235. doi: 10.1016/j.molmed.2017.12.008. Epub 2018 Feb 4.

Abstract or Full Text

Johansson J. U., Brubaker W. D., Javitz H., Bergen A. W., Nishita D., Trigunaite A., Crane A., Ceballos J., Mastroeni D., Tenner A.J., Sabbagh M., Rogers J. Peripheral complement interactions with amyloid β peptide (Aβ) in Alzheimer’s disease: polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement. 2018 Nov;14(11):1438-1449. doi: 10.1016/j.jalz.2018.04.003. Epub 2018 May 21.

Abstract or Full Text

Hinney, A. et al. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry. 2017 Feb;22(2):192-201. doi: 10.1038/mp.2016.71. Epub 2016 May 17.

Abstract or Full Text

Schuit, E., Panagiotou, O. A., Munafò, M. R., Bennett, D. A., Bergen, A. W., David, S. P. (2017). Pharmacotherapy for smoking cessation: effects by subgroup defined by genetically informed biomarkers. Cochrane Database Syst Rev. 2017 Sep 8;9:CD011823. doi: 10.1002/14651858.CD011823.pub2.

Abstract or Full Text

Duncan, L., Yilmaz, Z., Gaspar, H., Walters, R., Goldstein, J., Anttila, V., Bulik-Sullivan, B., Ripke, S. Eating Disorders Working Group of the Psychiatric Genomics Consortium., Thornton, L., Hinney, A., Daly, M., Sullivan, P. F., Zeggini, E., Breen, G., Bulik, C. M. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. Am J Psychiatry. 2017 Sep 1;174(9):850-858. doi: 10.1176/appi.ajp.2017.16121402.

Abstract or Full Text

Schwantes-An, T. H., et al. (2016). Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 2016 Mar;46(2):151-69.

Abstract or Full Text

Shih, P. B, Yang, J., Morisseau, C., German, J. B., Zeeland, A. A., Armando, A. M., Quehenberger, O., Bergen, A. W., Magistretti, P., Berrettini, W., Halmi, K.A,, Schork, N., Hammock, B. D., & Kaye, W. (2016). Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry. 2016 Apr;21(4):537-46.

Abstract or Full Text

David, S. P., Wang, A., Kapphahn, K., Hedlin, H., Desai, M., Henderson, M., Yang, L., Walsh, K. M., Schwartz, A. G., Wiencke, J. K., Spitz, M. R., Wenzlaff, A. S., Wrensch, M. R., Eaton, C. B., Furberg, H., Mark Brown, W., Goldstein, B. A., Assissmes, T., Tang, H., Kooperberg, C. L., Quesenberry, C. P., Tindle, H., Patel, M. I., Amos, C. I., Bergen, A. W., Swan, G. E., & Stefanick, M. L. Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. (2016). EBioMedicine. 2016 Jan 11;4:153-61. doi: 10.1016/j.ebiom.2016.01.002. eCollection 2016 Feb.

Abstract or Full Text

Baurley, J.W., Edlund, C.K., Pardamean, C.,, Conti, D. V., Krasnow, R., Javitz, H. S., Hops, H., Swan, G., Benowitz. N. L., & Bergen, A. W. (2016). Genome-wide association of the laboratory-based nicotine metabolite ratio in three ancestries. Nicotine Tob Res. 2016 Sep;18(9):1837-1844.

Abstract or Full Text

Guo, Y., Wei, Z., Keating, B. J.; Genetic Consortium for Anorexia Nervosa; Wellcome Trust Case Control Consortium; Price Foundation Collaborative Group, & Hakonarson, H. (2016). Machine learning derived risk prediction of anorexia nervosa. BMC Med Genomics. 2016 Jan 20;9:4.

Abstract or Full Text

Baurley, J. W., Edlund, C. K., Pardamean, C. I., Conti, D. V., Bergen, A. W. (2016). Smokescreen: a targeted genotyping array for addiction research. BMC Genomics. 2016 Feb 27;17:145.

Abstract or Full Text

Bergen, A. W., Krasnow, R., Javitz, H. S., Swan, G. E., Li, M. D., Baurley, J. W., Chen, X., Murrelle, L., & Zedler, B. Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures (2015). BMC Public Health. 2015 Sep 7;15:866.

Abstract or Full Text

Experience

2019
Board Member, Oregon Research Institute

2018 - present
Member, Mental Health Advisory/Local Alcohol and Drug Planning Committee, Lane County Board of Commissioners, Lane County, OR

2018 - present
Consultant, BioRealm, LLC

2017- present
Senior Scientist,
Oregon Research Institute, Eugene, OR

2017
Consultant,
Westat, Inc., Rockville, MD

2017
Consultant,
Granite Point Ventures, Greenbelt, MD

2015-present
Associate,
BioRealm LLC, Culver City, CA

2015-present
Member,
Pharmacogenomics Research Network: Pharmacogenetics of Nicotine Addiction Treatment (PGRN-PNAT) Research Group

2014-present
Member,
Tobacco Addiction Group, Cochrane Collaboration

2014-present
Member,
Psychiatric Genomics Consortium

2014-present
Scientific Advisor,
BioRealm, LLC, Culver City, CA

2014
Center for Tobacco and Alcohol Studies Visiting Professorship,
School of Experimental Psychology,
University of Bristol, Bristol, England

2011
Statistical Analysis of Genome Scale Data,
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

2007-2015
Director, Program in Molecular Genetics
Center for Health Sciences
SRI International, Menlo Park, CA

2007-2014
Co-Investigator,
Pharmacogenetics of Nicotine Addiction Treatment Consortium

2002-2006
Member, Core Genotyping Facility User Oversight Committee,
DCEG, National Cancer Institute, Rockville, MD

2002-2006
Adjunct Assistant Professor,Epidemiology and Biostatistics,
George Washington University, District of Columbia

2002-2007
Staff Scientist, Division of Cancer Epidemiology and Genetics,
National Cancer Institute, Bethesda, MD

2002-2006
Principal, Andrew W. Bergen, LLC

1999-2001
Co-Founder, Laboratory Director & Vice President,
Biognosis U.S., Inc., Gaithersburg, MD

1999-present
Co-Investigator, Environment and Genetics in Lung Cancer Etiology,
DCEG, National Cancer Institute, Rockville, MD

1998
Twin and Family Studies Workshop,
Institute for Behavioral Genetics, University of Colorado, Boulder, CO

1998
Genetic-Epidemiologic Studies of Complex Diseases,
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

1999-2001
Co-Founder, Laboratory Director, & Vice President,
Biognosis U.S. Inc., Gaithersburg, MD

1997-1999
Cancer Genetics and Epidemiology Post-Doctoral Fellowship,
National Cancer Institute, Rockville, MD

1996-1997
Post-Doctoral IRTA, Fellowship,
National Institute of Alcoholism and Alcohol Abuse, Rockville, MD

1993-1996
Pre-Doctoral IRTA Fellowship,
National Institute of Alcoholism and Alcohol Abuse, Rockville, MD

1989
Mammalian Genetics,
Jackson Laboratory, Bar Harbor, ME

1988-1991
NIH Pre-Doctoral Training Award,
Johns Hopkins University, Baltimore, MD

1987-1988
Research Associate,
Cellmark Diagnostics, Germantown, MD

1985-1987
Research Technician, Department of Biochemistry,
School of Hygiene and Public Health,
Johns Hopkins University, Baltimore, MD