Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep Duration and Timing to Reward- and Stress- Related Brain Function

Investigators are studying the relationship between sleep and depressive symptoms in youth with the goal of preventing depression.

The long-term objectives of this study are: to evaluate a biobehavioral model of depressive symptoms and anhedonia in adolescents, and to leverage sleep and circadian function to promote mental health. The investigators posit that sleep duration and/or timing moderate the effects of stressful events on depressive symptoms and anhedonia by disrupting reward- and stress-related brain function.

The investigative team has expertise in the etiology and prevention of depression in adolescents, including specific expertise in the impact of sleep and stressful life events on the stress and reward systems that contribute to depression and anhedonia. All four investigators are also licensed clinical psychologists who are committed to translating research on the mechanisms of psychopathology to preventative interventions.

This is a sub-award with the University of Oregon from NIDA.


2/10/22 - 12/31/26


National Institute on Drug Abuse (NIDA)