Salivary Biomarkers (DNA, RNA and Cortisol), Life Stress and Nicotine Dependence

The broad goal of this project was to lay the foundation for research identifying salivary biomarkers that predict vulnerability of individuals to become nicotine dependent, given their exposure to life stress.

This project has the potential to advance drug abuse prevention and intervention research through identifying Genetic x Environment (GxE) interactions, which may help to explain the success or failure of interventions designed to prevent the initiation of tobacco use and the progression to nicotine dependence, or to maintain cessation.


9/30/09 - 8/31/12


National Institute on Drug Abuse (NIDA)